YOHIMBINOS

Yohimbine is an indolalkylamine alkaloid mainly used as a fat burner. However, it is also an effective treatment for erectile dysfunction and possesses mydriatic properties. The component belongs to the class of alkaloids with alpha-2-adrenergic blocking activity. It affects presynaptic alpha-2 adrenergic receptors, blocking them.

According to the action on peripheral blood vessels, the component has a similar effect of reserpine, though it is weaker and causes short duration. The main impact of Yohimbine's peripheral autonomic nervous system is aimed at increasing parasympathetic (cholinergic) and decreasing sympathetic (adrenergic) activity. If we consider male sexual performance, erection is linked to cholinergic activity and alpha-2 adrenergic blockade. As a result, the effect is increased penile inflow and decreased penile outflow.

Besides, Yohimbine also has an effect on mood and may increase anxiety sometimes. Note that such actions have not been adequately studied or related to dosage. However, they are noticed when the treatment dose is high.

Yohimbine has a mild antidiuretic action. It is likely to appear due to stimulation of the hypothalamic center and the release of posterior pituitary hormone.

As for the cardiovascular system, no significant influence of Yohimbine is reported. It also does not have effects mediated by (beta)-adrenergic receptors. The component does not affect blood pressure significantly. If any impact is observed, it lowers it. Yet, no studies have proved any connection between Yohimbine dosage and blood pressure surges.